Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES)

Ursodeoxycholic acid versus placebo in the treatment of women with intrahepatic cholestasis of pregnancy (ICP) to improve perinatal outcomes: protocol for a randomised controlled trial (PITCHES)

Abstract Background Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy and presents with maternal pruritus, raised concentrations of serum bile acids and abnormal liver function tests. ICP is associated with increased rates of spontaneous and iatrogen...

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Bibliographic Details
Main Authors: Lucy C. Chappell, Jenny Chambers, Peter H. Dixon, Jon Dorling, Rachael Hunter, Jennifer L. Bell, Ursula Bowler, Pollyanna Hardy, Edmund Juszczak, Louise Linsell, Catherine Rounding, Anne Smith, Catherine Williamson, Jim G. Thornton
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Trials
Subjects:
Cholestasis
Pregnancy
Ursodeoxycholic acid
Perinatal
Stillbirth
Online Access:http://link.springer.com/article/10.1186/s13063-018-3018-4

Internet

http://link.springer.com/article/10.1186/s13063-018-3018-4

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