Circumventricular Organ Apelin Receptor Knockdown Decreases Blood Pressure and Sympathetic Drive Responses in the Spontaneously Hypertensive Rat

Circumventricular Organ Apelin Receptor Knockdown Decreases Blood Pressure and Sympathetic Drive Responses in the Spontaneously Hypertensive Rat

The central site(s) mediating the cardiovascular actions of the apelin-apelin receptor (APJ) system remains a major question. We hypothesized that the sensory circumventricular organs (CVOs), interfacing between the circulation and deeper brain structures, are sites where circulating apelin acts as...

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Bibliographic Details
Main Authors: Philip R. Griffiths, Stephen J. Lolait, Julian F. R. Paton, Anne-Marie O’Carroll
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
apelin
apelin receptor (APJ)
circumventricular organs (CVOs)
hypertension
spontaneously hypertensive rat (SHR)
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.711041/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.711041/full

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