Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

Adipose tissue fibrosis development blocks adipocyte hypertrophy and favors ectopic lipid accumulation. Here, we show that adipose tissue fibrosis is associated with obesity and insulin resistance in humans and mice. Kinetic studies in C3H mice fed a high-fat diet show activation of macrophages and...

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Bibliographic Details
Main Authors: Isabelle K. Vila, Pierre-Marie Badin, Marie-Adeline Marques, Laurent Monbrun, Corinne Lefort, Lucile Mir, Katie Louche, Virginie Bourlier, Balbine Roussel, Philippe Gui, Jacques Grober, Vladimír Štich, Lenka Rossmeislová, Alexia Zakaroff-Girard, Anne Bouloumié, Nathalie Viguerie, Cedric Moro, Geneviève Tavernier, Dominique Langin
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714002599

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http://www.sciencedirect.com/science/article/pii/S2211124714002599

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