Evaluation of Fluorine-18-Labeled α1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase

Evaluation of Fluorine-18-Labeled α1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase

Accumulating evidence suggests an unequivocal role of lysyl oxidases as key players of tumor progression and metastasis, which renders this enzyme family highly attractive for targeted non-invasive functional imaging of tumors. Considering their function in matrix remodeling, malignant melanoma appe...

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Bibliographic Details
Main Authors: Manuela Kuchar, Christin Neuber, Birgit Belter, Ralf Bergmann, Jens Lenk, Robert Wodtke, Torsten Kniess, Jörg Steinbach, Jens Pietzsch, Reik Löser
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Chemistry
Subjects:
lysyl oxidase
collagen
extracellular matrix
molecular imaging
pharmacokinetics
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00121/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00121/full

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