Delivery Pathway Regulation of 3′,3″-Bis-Peptide-siRNA Conjugate via Nanocarrier Architecture Engineering

Small interfering RNA (siRNA) has been continuously explored for clinical applications. However, neither nanocarriers nor conjugates have been able to remove the obstacles. In this study, we employed a combined nanochemistry strategy to optimize its delivery dilemma, where different interactions and...

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Bibliographic Details
Main Authors: Jing Sun, Chong Qiu, Yiping Diao, Wei Wei, Hongwei Jin, Yi Zheng, Jiancheng Wang, Lihe Zhang, Zhenjun Yang
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S216225311730286X