Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat

Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat

3,4-methylenedioxypyrovalerone (MDPV) is a potent pyrovalerone cathinone that is substituted for amphetamines by recreational users. We report a comprehensive and detailed description of the effects of subcutaneous MDPV (1–4 mg/kg) on pharmacokinetics, biodistribution and metabolism, acute effects o...

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Bibliographic Details
Main Authors: Rachel R. Horsley, Eva Lhotkova, Katerina Hajkova, Barbara Feriancikova, Michal Himl, Martin Kuchar, Tomas Páleníček
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Psychiatry
Subjects:
3 4-methylenedioxypyrovalerone
behaviour
hyperthermia
locomotion
MDPV
pharmacokinetics
Online Access:http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00144/full

Internet

http://journal.frontiersin.org/article/10.3389/fpsyt.2018.00144/full

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