Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis

Abstract Background Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA methylation, which is a stable and cell type-specific regulatory epigene...

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Bibliographic Details
Main Authors: Lara Kular, Maria Needhamsen, Milena Z. Adzemovic, Tatiana Kramarova, David Gomez-Cabrero, Ewoud Ewing, Eliane Piket, Jesper Tegnér, Stephan Beck, Fredrik Piehl, Lou Brundin, Maja Jagodic
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Clinical Epigenetics
Subjects:
Multiple sclerosis
Neurons
DNA methylation
DNA hydroxymethylation
Axonal guidance
Synaptic plasticity
Online Access:http://link.springer.com/article/10.1186/s13148-019-0678-1

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http://link.springer.com/article/10.1186/s13148-019-0678-1

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