A single, continuous metric to define tiered serum neutralization potency against HIV

A single, continuous metric to define tiered serum neutralization potency against HIV

HIV-1 Envelope (Env) variants are grouped into tiers by their neutralization-sensitivity phenotype. This helped to recognize that tier 1 neutralization responses can be elicited readily, but do not protect against new infections. Tier 3 viruses are the least sensitive to neutralization. Because most...

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Bibliographic Details
Main Authors: Peter Hraber, Bette Korber, Kshitij Wagh, David Montefiori, Mario Roederer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
vaccines
antibodies
neutralization
serology
logistic regression
clinical trials
Online Access:https://elifesciences.org/articles/31805

Internet

https://elifesciences.org/articles/31805

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