Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

O-GlcNAcylation is an abundant post-translational modification in the nervous system, linked to both neurodevelopmental and neurodegenerative disease. However, the mechanistic links between these phenotypes and site-specific O-GlcNAcylation remain largely unexplored. Here, we show that Ser517 O-GlcN...

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Bibliographic Details
Main Authors: Villo Muha, Ritchie Williamson, Rachel Hills, Alison D. McNeilly, Thomas G. McWilliams, Jana Alonso, Marianne Schimpl, Aneika C. Leney, Albert J. R. Heck, Calum Sutherland, Kevin D. Read, Rory J. McCrimmon, Simon P. Brooks, Daan M. F. van Aalten
Format: Article
Language:English
Published: The Royal Society 2019-11-01
Series:Open Biology
Subjects:
o-glcnacylation
crmp2
crosstalk
cognitive function
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190192

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.190192

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