Genetic Determinants in <i>HLA</i> and Cytochrome P450 Genes in the Risk of Aromatic Antiepileptic-Induced Severe Cutaneous Adverse Reactions

Genetic Determinants in <i>HLA</i> and Cytochrome P450 Genes in the Risk of Aromatic Antiepileptic-Induced Severe Cutaneous Adverse Reactions

Adverse drug reaction (ADR) is a pressing health problem, and one of the main reasons for treatment failure with antiepileptic drugs. This has become apparent in the event of severe cutaneous adverse reactions (SCARs), which can be life-threatening. In this review, four hypotheses were identified to...

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Bibliographic Details
Main Authors: Ali Fadhel Ahmed, Chonlaphat Sukasem, Majeed Arsheed Sabbah, Nur Fadhlina Musa, Dzul Azri Mohamed Noor, Nur Aizati Athirah Daud
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Personalized Medicine
Subjects:
HLA
cutaneous adverse drug reaction
SCAR
genetic polymorphism
antiepileptics
CYP450 enzymes
Online Access:https://www.mdpi.com/2075-4426/11/5/383

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https://www.mdpi.com/2075-4426/11/5/383

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