Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs.

Genetically-engineered pig-to-baboon liver xenotransplantation: histopathology of xenografts and native organs.

Orthotopic liver transplantation was carried out in baboons using wild-type (WT, n = 1) or genetically-engineered pigs (α1,3-galactosyltransferase gene-knockout, GTKO), n = 1; GTKO pigs transgenic for human CD46, n = 7) and a clinically-acceptable immunosuppressive regimen. Biopsies were obtained fr...

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Bibliographic Details
Main Authors: Burcin Ekser, Edwin Klein, Jing He, Donna B Stolz, Gabriel J Echeverri, Cassandra Long, Chih Che Lin, Mohamed Ezzelarab, Hidetaka Hara, Massimiliano Veroux, David Ayares, David K C Cooper, Bruno Gridelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22247784/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22247784/pdf/?tool=EBI

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