Intact B-Cell Signaling and Function With Host B-Cells 47 Years After Transplantation for X-SCID

Introduction: Severe Combined Immunodeficiency (SCID) is a life-threatening immunodeficiency caused by several pathogenic genetic variants, and it is characterized by profound defects in T-cell numbers and immune function. First performed in the late 1960's, hematopoietic stem cell transplantat...

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Bibliographic Details
Main Authors: Christin Deal, Timothy J. Thauland, E. Richard Stiehm, Maria I. Garcia-Lloret, Manish J. Butte
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00415/full