Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice

Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice

Abstract Background Studies on the relationship between osteoporosis and intervertebral disc degeneration (IVDD) are inconsistent. Therefore, we assessed whether IVDD is affected by vertebral osteoporosis in ovariectomized mice and investigated the underlying pathogenesis of IVDD related to osteopor...

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Bibliographic Details
Main Authors: Zhi-feng Xiao, Jian-bo He, Guo-yi Su, Mei-hui Chen, Yu Hou, Shu-dong Chen, Ding-kun Lin
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Arthritis Research & Therapy
Subjects:
Intervertebral disc degeneration
Osteoporosis
Ovariectomy
Endplate
Osteochondral remodeling
Microcomputed tomography
Online Access:http://link.springer.com/article/10.1186/s13075-018-1701-1

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http://link.springer.com/article/10.1186/s13075-018-1701-1

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