HB-EGF–EGFR Signaling in Bone Marrow Endothelial Cells Mediates Angiogenesis Associated with Multiple Myeloma

HB-EGF–EGFR Signaling in Bone Marrow Endothelial Cells Mediates Angiogenesis Associated with Multiple Myeloma

Epidermal growth factor receptor (EGFR) and its ligand heparin-binding EGF-like growth factor (HB-EGF) sustain endothelial cell proliferation and angiogenesis in solid tumors, but little is known about the role of HB-EGF−EGFR signaling in bone marrow angiogenesis and multiple myeloma (MM)...

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Bibliographic Details
Main Authors: Luigia Rao, Donato Giannico, Patrizia Leone, Antonio Giovanni Solimando, Eugenio Maiorano, Concetta Caporusso, Loren Duda, Roberto Tamma, Rosanna Mallamaci, Nicola Susca, Alessio Buonavoglia, Matteo Claudio Da Vià, Domenico Ribatti, Vallì De Re, Angelo Vacca, Vito Racanelli
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
multiple myeloma
hb-egf
egfr
bone marrow angiogenesis
endothelial cells
Online Access:https://www.mdpi.com/2072-6694/12/1/173

Internet

https://www.mdpi.com/2072-6694/12/1/173

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