Focus on Causality in ESC/iPSC-Based Modeling of Psychiatric Disorders

Focus on Causality in ESC/iPSC-Based Modeling of Psychiatric Disorders

Genome-wide association studies (GWAS) have identified an increasing number of genetic variants that significantly associate with psychiatric disorders. Despite this wealth of information, our knowledge of which variants causally contribute to disease, how they interact, and even more so of the func...

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Bibliographic Details
Main Authors: Anke Hoffmann, Michael Ziller, Dietmar Spengler
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
patient-specific ipscs
schizophrenia
bipolar disorder
copy number variation
common variation
(epi-) genomic editing
massively parallel reporter assays
Online Access:https://www.mdpi.com/2073-4409/9/2/366

Internet

https://www.mdpi.com/2073-4409/9/2/366

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