LPS-Binding Protein Modulates Acute Renal Fibrosis by Inducing Pericyte-to-Myofibroblast Trans-Differentiation through TLR-4 Signaling

LPS-Binding Protein Modulates Acute Renal Fibrosis by Inducing Pericyte-to-Myofibroblast Trans-Differentiation through TLR-4 Signaling

During sepsis, the increased synthesis of circulating lipopolysaccharide (LPS)-binding protein (LBP) activates LPS/TLR4 signaling in renal resident cells, leading to acute kidney injury (AKI). Pericytes are the major source of myofibroblasts during chronic kidney disease (CKD), but their involvement...

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Bibliographic Details
Main Authors: Giuseppe Castellano, Alessandra Stasi, Rossana Franzin, Fabio Sallustio, Chiara Divella, Alessandra Spinelli, Giuseppe Stefano Netti, Enrico Fiaccadori, Vincenzo Cantaluppi, Antonio Crovace, Francesco Staffieri, Luca Lacitignola, Giuseppe Grandaliano, Simona Simone, Giovanni Battista Pertosa, Loreto Gesualdo
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
LPS-binding protein
fibrosis
pericyte
myofibroblast
endotoxemia-induced oliguric kidney injury
Online Access:https://www.mdpi.com/1422-0067/20/15/3682

Internet

https://www.mdpi.com/1422-0067/20/15/3682

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