Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator and haploinsufficiency of its KANSL1 subunit results in the Koolen-de Vries syndrome in humans. Here, the authors identify the BET protein BRD4 as evolutionary conserved co-factor of the NSL com...

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Bibliographic Details
Main Authors: Aline Gaub, Bilal N. Sheikh, M. Felicia Basilicata, Marie Vincent, Mathilde Nizon, Cindy Colson, Matthew J. Bird, James E. Bradner, Julien Thevenon, Michael Boutros, Asifa Akhtar
Format: Article
Language:English
Published: Nature Publishing Group 2020-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16103-0

Internet

https://doi.org/10.1038/s41467-020-16103-0

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