Inhibition of Transcription Induces Phosphorylation of YB-1 at Ser102 and Its Accumulation in the Nucleus

Inhibition of Transcription Induces Phosphorylation of YB-1 at Ser102 and Its Accumulation in the Nucleus

The Y-box binding protein 1 (YB-1) is an RNA/DNA-binding protein regulating gene expression in the cytoplasm and the nucleus. Although mostly cytoplasmic, YB-1 accumulates in the nucleus under stress conditions. Its nuclear localization is associated with aggressiveness and multidrug resistance of c...

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Bibliographic Details
Main Authors: Dmitry A. Kretov, Daria A. Mordovkina, Irina A. Eliseeva, Dmitry N. Lyabin, Dmitry N. Polyakov, Vandana Joshi, Bénédicte Desforges, Loic Hamon, Olga I. Lavrik, David Pastré, Patrick A. Curmi, Lev P. Ovchinnikov
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cells
Subjects:
yb-1
nuclear translocation
inhibition of transcription
phosphorylation
Online Access:https://www.mdpi.com/2073-4409/9/1/104

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https://www.mdpi.com/2073-4409/9/1/104

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