Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury

Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury

Abstract Background The recruitment of immune system cells into the central nervous system (CNS) has a profound effect on the outcomes of injury and disease. Glia-derived chemoattractants, including chemokines, play a pivotal role in this process. In addition, cytokines and chemokines influence the...

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Bibliographic Details
Main Authors: Lun Li, Li Ni, Robert F. Heary, Stella Elkabes
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Journal of Neuroinflammation
Subjects:
Innate immune receptors
Toll-like receptor
Spinal cord injury
Astrocyte
Macrophage
Microglia
Online Access:http://link.springer.com/article/10.1186/s12974-020-01748-x

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http://link.springer.com/article/10.1186/s12974-020-01748-x

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