Molecular Dynamic Simulation of the Porcine Pancreatic Lipase in Non-aqueous Organic Solvents

Molecular Dynamic Simulation of the Porcine Pancreatic Lipase in Non-aqueous Organic Solvents

This paper investigates the conformational stability of porcine pancreatic lipase (PPL) in three non-aqueous organic solvents, including dimethyl sulfoxide (DMSO), propylene glycol (PRG), and ethanol (EtOH) through molecular dynamic (MD) simulation. The root mean square deviations (RMSDs), radius of...

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Bibliographic Details
Main Authors: Zi-Shi Chen, Yi-Da Wu, Jin-Heng Hao, Yu-Jia Liu, Kang-Ping He, Wen-Hao Jiang, Mei-Jie Xiong, Yong-Si Lv, Shi-Lin Cao, Jie Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
molecular dynamics simulation
porcine pancreatic lipase
organic solvents
conformation
biocatalysis
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00676/full

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https://www.frontiersin.org/article/10.3389/fbioe.2020.00676/full

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