The Immunosuppressant FTY720 (Fingolimod) enhances Glycosaminoglycan depletion in articular cartilage

The Immunosuppressant FTY720 (Fingolimod) enhances Glycosaminoglycan depletion in articular cartilage

<p>Abstract</p> <p>Background</p> <p>FTY720 (Fingolimod) is a novel immunosuppressive drug investigated in clinical trials for organ transplantation and multiple sclerosis. It acts as a functional sphingosine-1-phosphate (S1P) receptor antagonist, thereby inhibiting the...

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Bibliographic Details
Main Authors: Stradner Martin H, Angerer Hannes, Ortner Thomas, Fuerst Florentine C, Setznagl Daniela, Kremser Marie-Luise, Hermann Josef, Graninger Winfried B
Format: Article
Language:English
Published: BMC 2011-12-01
Series:BMC Musculoskeletal Disorders
Subjects:
chondrocyte
fingolimod
FTY720
interleukin-1β
tumor necrosis factor-α
inducible nitric oxide synthase
glycosaminoglycan
Online Access:http://www.biomedcentral.com/1471-2474/12/279

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http://www.biomedcentral.com/1471-2474/12/279

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