MicroRNA induction by copy number gain is associated with poor outcome in squamous cell carcinoma of the lung

MicroRNA induction by copy number gain is associated with poor outcome in squamous cell carcinoma of the lung

Abstract Copy number gains in cancer genomes have been shown to induce oncogene expression and promote carcinogenesis; however, their role in regulating oncogenic microRNAs (onco-miRNAs) remains largely unknown. Our aim was to identify onco-miRNAs induced by copy number gains in human squamous cell...

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Bibliographic Details
Main Authors: Endi Xia, Sotaro Kanematsu, Yusuke Suenaga, Asmaa Elzawahry, Hitomi Kondo, Noriko Otsuka, Yasumitsu Moriya, Toshihiko Iizasa, Mamoru Kato, Ichiro Yoshino, Sana Yokoi
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Scientific Reports
Subjects:
Copy Number Alternations
The Cancer Genome Atlas (TCGA)
Induce Oncogene Expression
miRNA Mimic Transfection
Differentially Expressed miRNA (DEMI)
Online Access:https://doi.org/10.1038/s41598-018-33696-1

Internet

https://doi.org/10.1038/s41598-018-33696-1

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