Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal

Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal

Pulmonary arterial hypertension (PAH) is a progressive and lethal cardiopulmonary. Pulmonary vascular remodeling (PVR) caused by excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs) is the chief pathological feature of PAH. Dioscin is a natural product th...

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Bibliographic Details
Main Authors: Yueyue Yang, Lianhong Yin, Manning Zhu, Shasha Song, Changjie Sun, Xu Han, Youwei Xu, Yanyan Zhao, Yan Qi, Lina Xu, J.-Y. Peng
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Vascular remodeling
Pulmonary arterial smooth muscle cells
Dioscin
Molecular mechanism
GRB2/ERK/PI3K-AKT signal
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220312488

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http://www.sciencedirect.com/science/article/pii/S0753332220312488

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