Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes

Very Low-Density Lipoproteins of Metabolic Syndrome Modulates STIM1, Suppresses Store-Operated Calcium Entry, and Deranges Myofilament Proteins in Atrial Myocytes

Individuals with metabolic syndrome (MetS) are at high risk for atrial myopathy and atrial fibrillation. Very low-density lipoproteins (VLDLs) of MetS (MetS-VLDLs) are cytotoxic to atrial myocytes in vivo and in vitro. The calcineurin−nuclear factor of activated T-cells (NFAT) pathway, whi...

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Bibliographic Details
Main Authors: Yi-Lin Shiou, Hsin-Ting Lin, Liang-Yin Ke, Bin-Nan Wu, Shyi-Jang Shin, Chu-Huang Chen, Wei-Chung Tsai, Chih-Sheng Chu, Hsiang-Chun Lee
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Journal of Clinical Medicine
Subjects:
very low-density lipoprotein
metabolic syndrome
STIM1
SOCE
atrial myopathy
atrial fibrillation
Online Access:https://www.mdpi.com/2077-0383/8/6/881

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https://www.mdpi.com/2077-0383/8/6/881

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