Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion

Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion

Abstract Background The Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1 increases protein stability and function. We identify a novel signaling axis that leads to increased phosphorylation of FRA-1, increased extracellu...

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Bibliographic Details
Main Authors: Matthew G. Annis, Veronique Ouellet, Jonathan P. Rennhack, Sylvain L’Esperance, Claudine Rancourt, Anne-Marie Mes-Masson, Eran R. Andrechek, Peter M. Siegel
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Integrins
uPAR
FRA-1
Invasion
Online Access:http://link.springer.com/article/10.1186/s13058-018-0936-8

Internet

http://link.springer.com/article/10.1186/s13058-018-0936-8

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