Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

Approaching boiling point stability of an alcohol dehydrogenase through computationally-guided enzyme engineering

Enzyme instability is an important limitation for the investigation and application of enzymes. Therefore, methods to rapidly and effectively improve enzyme stability are highly appealing. In this study we applied a computational method (FRESCO) to guide the engineering of an alcohol dehydrogenase....

Full description

Bibliographic Details
Main Authors: Friso S Aalbers, Maximilian JLJ Fürst, Stefano Rovida, Milos Trajkovic, J Rubén Gómez Castellanos, Sebastian Bartsch, Andreas Vogel, Andrea Mattevi, Marco W Fraaije
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
biocatalysis
enzyme engineering
oxidations
biotechnology
alcohol dehydrogenase
cofactor
Online Access:https://elifesciences.org/articles/54639

Internet

https://elifesciences.org/articles/54639

Similar Items