IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes

IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes

Abstract Background Interferon lambdas (IFNLs) have important anti-viral/bacterial and immunomodulatory functions in the respiratory tract. How do IFNLs impact COPD and its exacerbations? Methods Five hundred twenty eight patients were recruited in a prospective observational multicentre cohort (PRO...

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Bibliographic Details
Main Authors: Adrian Egli, Jyotshna Mandal, Desiree M. Schumann, Michael Roth, Brad Thomas, D. Lorne Tyrrell, Francesco Blasi, Kostantinos Kostikas, Wim Boersma, Branislava Milenkovic, Alicia Lacoma, Katharina Rentsch, Gernot G. U. Rohde, Renaud Louis, Joachim G. Aerts, Tobias Welte, Antoni Torres, Michael Tamm, Daiana Stolz
Format: Article
Language:English
Published: BMC 2018-03-01
Series:BMC Pulmonary Medicine
Subjects:
Interleukin 28B
Cohort
Mortality
Biomarker
Single nucleotide polymorphisms
Online Access:http://link.springer.com/article/10.1186/s12890-018-0616-6

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http://link.springer.com/article/10.1186/s12890-018-0616-6

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