Central role of the gut epithelial barrier in pathogenesis of chronic intestinal inflammation: Lessons learned from animal models and human genetics

Central role of the gut epithelial barrier in pathogenesis of chronic intestinal inflammation: Lessons learned from animal models and human genetics

The gut mucosa is constantly challenged by a bombardment of foreign antigens and environmental microorganisms. As such, the precise regulation of the intestinal barrier allows the maintenance of mucosal immune homeostasis and prevents the onset of uncontrolled inflammation. In support of this conc...

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Bibliographic Details
Main Authors: Luca ePastorelli, Carlo eDe Salvo, Joseph R. Mercado, Maurizio eVecchi, Theresa T. Pizarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-09-01
Series:Frontiers in Immunology
Subjects:
innate immunity
ulcerative colitis
Crohn’s Disease
intestinal epithelial cells
intestinal barrier function
gut immune homeostasis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00280/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00280/full

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