Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.

Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.

Standard cancer cell lines do not model the intratumoural heterogeneity situation sufficiently. Clonal selection leads to a homogeneous population of cells by genetic drift. Heterogeneity of tumour cells, however, is particularly critical for therapeutically relevant studies, since it is a prerequis...

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Main Authors: Johannes Fredebohm, Michael Boettcher, Christian Eisen, Matthias M Gaida, Anette Heller, Shereen Keleg, Jörg Tost, Karin M Greulich-Bode, Agnes Hotz-Wagenblatt, Mark Lathrop, Nathalia A Giese, Jörg D Hoheisel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3495919?pdf=render

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http://europepmc.org/articles/PMC3495919?pdf=render

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