Probiotic Lactobacillus rhamnosus GG enhanced Th1 cellular immunity but did not affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig model.

Probiotic Lactobacillus rhamnosus GG enhanced Th1 cellular immunity but did not affect antibody responses in a human gut microbiota transplanted neonatal gnotobiotic pig model.

This study aims to establish a human gut microbiota (HGM) transplanted gnotobiotic (Gn) pig model of human rotavirus (HRV) infection and diarrhea, and to verify the dose-effects of probiotics on HRV vaccine-induced immune responses. Our previous studies using the Gn pig model found that probiotics d...

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Bibliographic Details
Main Authors: Ke Wen, Christine Tin, Haifeng Wang, Xingdong Yang, Guohua Li, Ernawati Giri-Rachman, Jacob Kocher, Tammy Bui, Sherrie Clark-Deener, Lijuan Yuan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3983166?pdf=render

Internet

http://europepmc.org/articles/PMC3983166?pdf=render

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