Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity

Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity

Abstract Background Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). Pilot studies have associated the rs805305 SNP of DDAH2 with ADMA concen...

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Bibliographic Details
Main Authors: Simon Lambden, James Tomlinson, Sophie Piper, Anthony C. Gordon, James Leiper
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Critical Care
Subjects:
Mortality/survival
Clinical studies
Translational studies
Genetics
Septic shock
Nitric oxide
Online Access:http://link.springer.com/article/10.1186/s13054-018-2277-5

Internet

http://link.springer.com/article/10.1186/s13054-018-2277-5

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