Challenges in validating candidate therapeutic targets in cancer

More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not. These reports highlight the caveats associated with some of the research tools that are commonly...

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Bibliographic Details
Main Authors: Jeffrey Settleman, Charles L Sawyers, Tony Hunter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/32402