Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues

Histological Evidence of Protein Aggregation in Mutant SOD1 Transgenic Mice and in Amyotrophic Lateral Sclerosis Neural Tissues

The mechanisms leading to neurodegeneration in ALS (amyotrophic lateral sclerosis) are not well understood, but cytosolic protein aggregates appear to be common in sporadic and familial ALS as well as transgenic mouse models expressing mutant Cu/Zn superoxide dismutase (SOD1). In this study, we syst...

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Bibliographic Details
Main Authors: Mitsunori Watanabe, Margaret Dykes-Hoberg, Valeria Cizewski Culotta, Donald L. Price, Philip C. Wong, Jeffrey D. Rothstein
Format: Article
Language:English
Published: Elsevier 2001-12-01
Series:Neurobiology of Disease
Subjects:
SOD1
copper chaperone for SOD1
hyaline inclusion
amyotrophic lateral sclerosis
ubiquitin-proteasome pathway
Hsc70
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904437

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http://www.sciencedirect.com/science/article/pii/S0969996101904437

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