Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli

Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli

Abstract Background As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal role in extracellular matrix remodeling, which is involved in a wide variety of physiological processes. Since abnormal meta...

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Bibliographic Details
Main Authors: Ki Baek Lee, Dong Hyun Nam, Jacob A. M. Nuhn, Juan Wang, Ian C. Schneider, Xin Ge
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Microbial Cell Factories
Subjects:
Tissue inhibitor of metalloproteinase
Matrix metalloproteinase
Periplasmic expression
Disulfide isomerase
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Online Access:http://link.springer.com/article/10.1186/s12934-017-0686-9

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http://link.springer.com/article/10.1186/s12934-017-0686-9

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