Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological Mechanisms, Pharmacological Interventions, and Genetic Mitigations

Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular uptake and efflux, apoptosis, vascular injury, oxidative and endoplasmic reticulum stress, and inflammation...

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Bibliographic Details
Main Authors: Kristen Renee McSweeney, Laura Kate Gadanec, Tawar Qaradakhi, Benazir Ashiana Ali, Anthony Zulli, Vasso Apostolopoulos
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
cisplatin
acute kidney injury
AKI
cisplatin-induced acute kidney injury
nephrotoxicity
Online Access:https://www.mdpi.com/2072-6694/13/7/1572

Internet

https://www.mdpi.com/2072-6694/13/7/1572

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