NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses

NOD2 and TLR2 recognize components of bacterial cell wall peptidoglycan and direct defense against enteric pathogens. CD8+ T cells are important for immunity to such pathogens but how NOD2 and TLR2 induce antigen specific CD8+ T cell responses is unknown. Here, we define how these pattern recognitio...

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Bibliographic Details
Main Authors: Daniele Corridoni, Seiji Shiraishi, Thomas Chapman, Tessa Steevels, Daniele Muraro, Marie-Laëtitia Thézénas, Gennaro Prota, Ji-Li Chen, Uzi Gileadi, Nicola Ternette, Vincenzo Cerundolo, Alison Simmons
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
innate immunity
NOD2
TLR2
cross-presentation
CD8+ T cells
Crohn's disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00958/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00958/full

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