Use of Proteomic Imaging Coupled With Transcriptomic Analysis to Identify Biomolecules Responsive to Cochlear Injury

Use of Proteomic Imaging Coupled With Transcriptomic Analysis to Identify Biomolecules Responsive to Cochlear Injury

Exposure to noise or ototoxic agents can result in degeneration of cells in the sensory epithelium and auditory nerve, as well as non-sensory cells of the cochlear lateral wall. However, the molecular mechanisms underlying this pathology remain unclear. The purpose of this study was to localize and...

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Bibliographic Details
Main Authors: Kenyaria V. Noble, Michelle L. Reyzer, Jeremy L. Barth, Hayes McDonald, Michael Tuck, Kevin L. Schey, Edward L. Krug, Hainan Lang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cochlea
hearing loss
MALDI-TOF IMS
microarray
noise
ouabain
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00243/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00243/full

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