Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity

Abstract Multiple sclerosis (MS) is the most common autoimmune disease of the CNS. The etiology of MS is still unclear but it is widely recognized that both genetic and environmental factors contribute to its pathogenesis. Immune signaling and responses are critically regulated by ubiquitination, a...

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Bibliographic Details
Main Authors: Jing Ruan, Dirk Schlüter, Xu Wang
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12974-020-01783-8