Doxorubicin-Conjugated Innovative 16-mer DNA Aptamer-Based Annexin A1 Targeted Anti-Cancer Drug Delivery

Doxorubicin-Conjugated Innovative 16-mer DNA Aptamer-Based Annexin A1 Targeted Anti-Cancer Drug Delivery

Aptamers are small, functional single-stranded DNA or RNA oligonucleotides that bind to their targets with high affinity and specificity. Experimentally, aptamers are selected by the systematic evolution of ligands by exponential enrichment (SELEX) method. Here, we have used rational drug designing...

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Bibliographic Details
Main Authors: Rohit Bavi, Zhang Hang, Parikshit Banerjee, Md Aquib, Mahendra Jadhao, Niraj Rane, Sneha Bavi, Raghunath Bhosale, Kisan Kodam, Byong-Hun Jeon, Yueqing Gu
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
annexin A1
DNA1 aptamer
virtual screening
molecular dynamics simulation
binding energy calculations
aptamer-drug conjugate
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302274

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http://www.sciencedirect.com/science/article/pii/S2162253120302274

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