Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

Peripheral or central nerve injury is a frequent cause of chronic pain and the mechanisms are not fully understood. Using newly generated transgenic mice we show that progranulin overexpression in sensory neurons attenuates neuropathic pain after sciatic nerve injury and accelerates nerve healing. A...

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Bibliographic Details
Main Authors: Christine Altmann, Stefanie Hardt, Caroline Fischer, Juliana Heidler, Hee-Young Lim, Annett Häussler, Boris Albuquerque, Béla Zimmer, Christine Möser, Christian Behrends, Frank Koentgen, Ilka Wittig, Mirko H.H. Schmidt, Albrecht M. Clement, Thomas Deller, Irmgard Tegeder
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Pain
Nerve injury
Sensory neuron
Autophagy
Progranulin
Dorsal root ganglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302248

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http://www.sciencedirect.com/science/article/pii/S0969996116302248

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