Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab

Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab

Summary: Monoclonal antibodies (mAbs) targeting the co-stimulatory molecule 4-1BB are of interest for tumor immunotherapy. We determined the complex structures of human 4-1BB with 4-1BB ligand (4-1BBL) or utomilumab to elucidate the structural basis of 4-1BB activation. The 4-1BB/4-1BBL complex disp...

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Bibliographic Details
Main Authors: Yan Li, Shuguang Tan, Chang Zhang, Yan Chai, Mengnan He, Catherine W.-H. Zhang, Qihui Wang, Zhou Tong, Kefang Liu, Yifan Lei, William J. Liu, Yingxia Liu, Zhigang Tian, Xuetao Cao, Jinghua Yan, Jianxun Qi, Po Tien, Shan Gao, George F. Gao
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471831533X

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http://www.sciencedirect.com/science/article/pii/S221112471831533X

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