The impact of flow-induced forces on the morphogenesis of the outflow tract

The impact of flow-induced forces on the morphogenesis of the outflow tract

One percent of infants are born with congenital heart disease (CHD), which commonly involves outflow tract (OFT) defects. These infants often require complex surgeries, which are associated with long term adverse remodeling effects, and receive replacement valves with limited strength, biocompatibil...

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Bibliographic Details
Main Authors: Richard Lance Goodwin, Stefanie V Biechler, Lorain eJunor, Ashlie N Evans, John F Eberth, Robert L Price, Jay D Potts, Michael J Yost
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Physiology
Subjects:
Developmental Biology
Extracellular Matrix
Mechanotransduction
mechanical forces
Cardiac Valves
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00225/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00225/full

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