Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease

Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s disease

Abstract Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in Alzheimer’s disease (AD) dementia and is a common finding at autopsy. The APOEε4 allele and male sex have previously been reported to associate with increased CAA in AD. To inform biomarker and therapeutic tar...

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Bibliographic Details
Main Authors: Joseph S. Reddy, Mariet Allen, Charlotte C. G. Ho, Stephanie R. Oatman, Özkan İş, Zachary S. Quicksall, Xue Wang, Jiangli Jin, Tulsi A. Patel, Troy P. Carnwath, Thuy T. Nguyen, Kimberly G. Malphrus, Sarah J. Lincoln, Minerva M. Carrasquillo, Julia E. Crook, Takahisa Kanekiyo, Melissa E. Murray, Guojun Bu, Dennis W. Dickson, Nilüfer Ertekin-Taner
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Acta Neuropathologica Communications
Subjects:
Genome-wide association study
Cerebral amyloid angiopathy
Alzheimer’s disease
CAA
AD
LINC-PINT
Online Access:https://doi.org/10.1186/s40478-021-01199-2

Internet

https://doi.org/10.1186/s40478-021-01199-2

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