Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.

Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.

Airway mucociliary clearance (MCC) is an important defense mechanism against pulmonary infections and is compromised in cystic fibrosis (CF). Cl- and HCO3- epithelial transport are integral to MCC. During pulmonary infections prostaglandin E2 (PGE2) production is abundant.To determine the effect of...

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Bibliographic Details
Main Authors: Zachary M Sellers, Beate Illek, Miriam Frankenthal Figueira, Gopika Hari, Nam Soo Joo, Eric Sibley, Jackson Souza-Menezes, Marcelo M Morales, Horst Fischer, Jeffrey J Wine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5744969?pdf=render

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http://europepmc.org/articles/PMC5744969?pdf=render

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