Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling

Tamoxifen Treatment of Breast Cancer Cells: Impact on Hedgehog/GLI1 Signaling

The selective estrogen receptor (ER) modulator tamoxifen (TAM) has become the standard therapy for the treatment of ER+ breast cancer patients. Despite the obvious benefits of TAM, a proportion of patients acquire resistance to treatment, and this is a significant clinical problem. Consequently, the...

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Bibliographic Details
Main Authors: Victoria E. Villegas, Milena Rondón-Lagos, Laura Annaratone, Isabella Castellano, Adriana Grismaldo, Anna Sapino, Peter G. Zaphiropoulos
Format: Article
Language:English
Published: MDPI AG 2016-02-01
Series:International Journal of Molecular Sciences
Subjects:
GLI1
TAM resistance
breast cancer
Hedgehog signaling
cellular proliferation
Online Access:http://www.mdpi.com/1422-0067/17/3/308

Internet

http://www.mdpi.com/1422-0067/17/3/308

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