Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.

Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.

BACKGROUND: Double-stranded RNA dependent protein kinase (PKR) is a key regulator of the anti-viral innate immune response in mammalian cells. PKR activity is regulated by a 58 kilo Dalton cellular inhibitor (P58(IPK)), which is present in inactive state as a complex with Hsp40 under normal conditio...

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Bibliographic Details
Main Authors: Kulbhushan Sharma, Shashank Tripathi, Priya Ranjan, Purnima Kumar, Rebecca Garten, Varough Deyde, Jacqueline M Katz, Nancy J Cox, Renu B Lal, Suryaprakash Sambhara, Sunil K Lal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3115951?pdf=render

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http://europepmc.org/articles/PMC3115951?pdf=render

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