Cancer-Associated Fibroblast Mediated Inhibition of CD8+ Cytotoxic T Cell Accumulation in Tumours: Mechanisms and Therapeutic Opportunities

The tumour microenvironment (TME) is the complex environment in which various non-cancerous stromal cell populations co-exist, co-evolve and interact with tumour cells, having a profound impact on the progression of solid tumours. The TME is comprised of various extracellular matrix (ECM) proteins i...

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Bibliographic Details
Main Authors: Patrick Freeman, Ainhoa Mielgo
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
CAF
Online Access:https://www.mdpi.com/2072-6694/12/9/2687