Attenuated CSF‐1R signalling drives cerebrovascular pathology

Attenuated CSF‐1R signalling drives cerebrovascular pathology

Abstract Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood–brain barrier (BBB) disruption are still not fully understood. We have identified previously unreported mutation...

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Bibliographic Details
Main Authors: Conor Delaney, Michael Farrell, Colin P Doherty, Kiva Brennan, Eoin O’Keeffe, Chris Greene, Kieva Byrne, Eoin Kelly, Niamh Birmingham, Paula Hickey, Simon Cronin, Savvas N Savvides, Sarah L Doyle, Matthew Campbell
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:EMBO Molecular Medicine
Subjects:
adult‐onset leucoencephalopathy with axonal spheroids and pigmented glia (ALSP)
blood
brain barrier
CSF‐1
CSF‐1R
IL‐34
Online Access:https://doi.org/10.15252/emmm.202012889

Internet

https://doi.org/10.15252/emmm.202012889

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