Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease

6-Hydroxydopamine (6-OHDA) lesions are being used in the mouse for basic research on Parkinson's disease and L-DOPA-induced dyskinesia. We set out to compare unilateral lesion models produced by intrastriatal or intramesencephalic injections of a fixed 6-OHDA concentration (3.2 μg/μl) in C57BL/...

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Bibliographic Details
Main Authors: Veronica Francardo, Alessandra Recchia, Nataljia Popovic, Daniel Andersson, Hans Nissbrandt, M. Angela Cenci
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Motor complications
Neurotoxin
6-Hydroxydopamine
Rotation
Nigrostriatal pathway
Monoamine
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000453

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http://www.sciencedirect.com/science/article/pii/S0969996111000453

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