Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer?

Recalling the Biological Significance of Immune Checkpoints on NK Cells: A Chance to Overcome LAG3, PD1, and CTLA4 Inhibitory Pathways by Adoptive NK Cell Transfer?

Immune checkpoint receptors (IC) positively or negatively regulate the activation of the host immune response, preventing unwanted reactions against self-healthy tissues. In recent years the term IC has been mainly used for the inhibitory ICs, which are critical to control Natural Killer (NK) and Cy...

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Bibliographic Details
Main Authors: Pilar M. Lanuza, Cecilia Pesini, Maykel A. Arias, Carlota Calvo, Ariel Ramirez-Labrada, Julian Pardo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
NK cell
adoptive cell therapy
T cell
immune check point
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03010/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03010/full

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